DEALing with protein microarrays
نویسندگان
چکیده
منابع مشابه
Dealing with Futile Fears
بدون ترس شانس کمتری برای رسیدن به دوران تکاملی داریم. ترس منطقی به ما می گوید که از چه چیز پرهیز کنیم، به ما کمک می کند که با مشکلات روبرو شویم و ما را در مقابل خطرات حقبقی محافظت می کند. در طرف دیگر آن نوع ترس هائی که از مقوله ترسهای مرضی است، غیرمنطقی می باشد و آثار فیزیکی و روحی بی شماری را باعث می گردد.
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Protein microarrays, an emerging class of proteomic technologies, are fast becoming critical tools in biochemistry and molecular biology. Two classes of protein microarrays are currently available: analytical and functional protein microarrays. Analytical protein microarrays, mostly antibody microarrays, have become one of the most powerful multiplexed detection technologies. Functional protein...
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The regulation of protein function through posttranslational modification, local environment, and protein-protein interaction is critical to cellular function. The ability to analyze on a genome-wide scale protein functional activity rather than changes in protein abundance or structure would provide important new insights into complex biological processes. Herein, we report the application of ...
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MOTIVATION Microarray expression data reveal functionally associated proteins. However, most proteins that are associated are not actually in direct physical contact. Predicting physical interactions directly from microarrays is both a challenging and important task that we addressed by developing a novel machine learning method optimized for this task. RESULTS We validated our support vector...
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References 1. Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003;348:1986–94. 2. Peiris J, Lai S, Poon L, Guan Y, Yam L, Lim W, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003;361: 1319–25. 3. Ng EKO, Hui DS, Chan AKC, Hung ECW, Chiu RWK, Lee N, et al. Quantitative...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2007
ISSN: 1548-7091,1548-7105
DOI: 10.1038/nmeth0407-304